diff --git a/src/lib/list/selection-list.spec.ts b/src/lib/list/selection-list.spec.ts
index ff75fb24088..73b6b610d04 100644
--- a/src/lib/list/selection-list.spec.ts
+++ b/src/lib/list/selection-list.spec.ts
@@ -196,6 +196,26 @@ describe('MatSelectionList without forms', () => {
       expect(ENTER_EVENT.defaultPrevented).toBe(true);
     });
 
+    it('should not be able to toggle an item when pressing a modifier key', () => {
+      const testListItem = listOptions[1].nativeElement as HTMLElement;
+      const selectList =
+          selectionList.injector.get<MatSelectionList>(MatSelectionList).selectedOptions;
+
+      expect(selectList.selected.length).toBe(0);
+
+      [ENTER, SPACE].forEach(key => {
+        const event = createKeyboardEvent('keydown', key, testListItem);
+        Object.defineProperty(event, 'ctrlKey', { get: () => true });
+
+        dispatchFakeEvent(testListItem, 'focus');
+        selectionList.componentInstance._keydown(event);
+        fixture.detectChanges();
+        expect(event.defaultPrevented).toBe(false);
+      });
+
+      expect(selectList.selected.length).toBe(0);
+    });
+
     it('should not be able to toggle a disabled option using SPACE', () => {
       const testListItem = listOptions[1].nativeElement as HTMLElement;
       const selectionModel = selectionList.componentInstance.selectedOptions;
@@ -332,6 +352,20 @@ describe('MatSelectionList without forms', () => {
       expect(event.defaultPrevented).toBe(true);
     });
 
+    it('should not change focus when pressing HOME with a modifier key', () => {
+      const manager = selectionList.componentInstance._keyManager;
+      expect(manager.activeItemIndex).toBe(-1);
+
+      const event = createKeyboardEvent('keydown', HOME);
+      Object.defineProperty(event, 'shiftKey', { get: () => true });
+
+      dispatchEvent(selectionList.nativeElement, event);
+      fixture.detectChanges();
+
+      expect(manager.activeItemIndex).toBe(-1);
+      expect(event.defaultPrevented).toBe(false);
+    });
+
     it('should focus the last item when pressing END', () => {
       const manager = selectionList.componentInstance._keyManager;
       expect(manager.activeItemIndex).toBe(-1);
@@ -343,6 +377,20 @@ describe('MatSelectionList without forms', () => {
       expect(event.defaultPrevented).toBe(true);
     });
 
+    it('should not change focus when pressing END with a modifier key', () => {
+      const manager = selectionList.componentInstance._keyManager;
+      expect(manager.activeItemIndex).toBe(-1);
+
+      const event = createKeyboardEvent('keydown', END);
+      Object.defineProperty(event, 'shiftKey', { get: () => true });
+
+      dispatchEvent(selectionList.nativeElement, event);
+      fixture.detectChanges();
+
+      expect(manager.activeItemIndex).toBe(-1);
+      expect(event.defaultPrevented).toBe(false);
+    });
+
     it('should select all items using ctrl + a', () => {
       const event = createKeyboardEvent('keydown', A, selectionList.nativeElement);
       Object.defineProperty(event, 'ctrlKey', {get: () => true});
diff --git a/src/lib/list/selection-list.ts b/src/lib/list/selection-list.ts
index 4d6adeeef88..06934817a22 100644
--- a/src/lib/list/selection-list.ts
+++ b/src/lib/list/selection-list.ts
@@ -9,7 +9,16 @@
 import {FocusableOption, FocusKeyManager} from '@angular/cdk/a11y';
 import {coerceBooleanProperty} from '@angular/cdk/coercion';
 import {SelectionModel} from '@angular/cdk/collections';
-import {SPACE, ENTER, HOME, END, UP_ARROW, DOWN_ARROW, A} from '@angular/cdk/keycodes';
+import {
+  SPACE,
+  ENTER,
+  HOME,
+  END,
+  UP_ARROW,
+  DOWN_ARROW,
+  A,
+  hasModifierKey,
+} from '@angular/cdk/keycodes';
 import {
   AfterContentInit,
   Attribute,
@@ -417,21 +426,26 @@ export class MatSelectionList extends _MatSelectionListMixinBase implements Focu
     const keyCode = event.keyCode;
     const manager = this._keyManager;
     const previousFocusIndex = manager.activeItemIndex;
+    const hasModifier = hasModifierKey(event);
 
     switch (keyCode) {
       case SPACE:
       case ENTER:
-        this._toggleFocusedOption();
-        // Always prevent space from scrolling the page since the list has focus
-        event.preventDefault();
+        if (!hasModifier) {
+          this._toggleFocusedOption();
+          // Always prevent space from scrolling the page since the list has focus
+          event.preventDefault();
+        }
         break;
       case HOME:
       case END:
-        keyCode === HOME ? manager.setFirstItemActive() : manager.setLastItemActive();
-        event.preventDefault();
+        if (!hasModifier) {
+          keyCode === HOME ? manager.setFirstItemActive() : manager.setLastItemActive();
+          event.preventDefault();
+        }
         break;
       case A:
-        if (event.ctrlKey) {
+        if (hasModifierKey(event, 'ctrlKey')) {
           this.options.find(option => !option.selected) ? this.selectAll() : this.deselectAll();
           event.preventDefault();
         }